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Healthy, functional joints are something most people take for granted. Unfortunately, joints can deteriorate with age. Joint health may deteriorate due to a number of causes, from overuse to your own immune system attacking your joints.Â
With an estimated 1 in 5 adults having some form of arthritis, maybe it is time to take action? For some people, diet changes or physical therapy may be enough, while others may take medications prescribed by their healthcare provider.
Another popular option are nutritional supplements, as some studies suggest they may help with joint pain. The issue is, as certain supplements may be better than others, it is hard for many people to know which to use. This guide to the best supplements for arthritis on the market in 2025 can help everyone find the perfect option for them.
Reviewing The 10 Best Joint Pain Supplements In 2025
Based on a comparison of the most popular supplements of this kind using vital criteria like their ingredients, effects, and price, this list should feature an ideal joint supplement for each and every person.Â
– Best Single Ingredient SupplementsÂ
– Best Joint Supplement (combined)
– Best Budget Joint Supplement
Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D
Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root
Nordic Naturals Vegan Algae Omega - Best For Joint Lubrication
Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM
U.S. Doctors' Clinical Arthro-7 Healthy Joint Support
Physio Flex Pro
Nuzena Joint Support +
Relief Factor
– Best Single-Ingredient Supplements for Joints
Elm & Rye has carved out a reputation for offering premium-quality, single-ingredient supplements — and their joint health lineup is no exception. Rather than packing everything into one capsule, Elm & Rye allows users to customize their stack with high-quality compounds like glucosamine, turmeric, and omega-3s — each designed to target joint pain, inflammation, and overall mobility.
Their glucosamine supplement may support cartilage health and help maintain joint cushioning, potentially reducing wear and tear over time. The turmeric extract (standardized for curcumin) may offer anti-inflammatory and antioxidant effects, ideal for reducing joint stiffness and combating chronic inflammation. And their omega-3 supplement has high-purity EPA and DHA — fatty acids that may help reduce joint pain, stiffness, and swelling, especially in those with osteoarthritis or rheumatoid arthritis.
By isolating and optimizing each key ingredient, Elm & Rye lets users focus on what their joints actually need, whether that’s reducing inflammation, rebuilding cartilage, or improving long-term joint resilience.
Pros
Allows you to precisely target joint concerns
Glucosamine may support cartilage repair and reduce degeneration
Turmeric and omega-3 may fight inflammation and stiffness
High-quality, third-party tested formulas
Flexible dosing options — build your own stack
Conclusion
Elm & Rye is the best option in 2025 for those who prefer a modular, high-potency approach to joint care. Their single-ingredient supplements allow for tailored support, whether you’re looking to help rebuild cartilage, reduce chronic inflammation, or simply keep your joints functioning optimally as you age. With transparent sourcing, they offer an elite, customizable route to joint health.
FlexAgain - Best Combined Supplement For Joints
FlexAgain is a fairly new supplement packed full of optimally dosed natural ingredients that may help provide joint pain relief. With its incredibly diverse formula, it approaches joint health from countless angles, and may offer other health benefits.
Its anti-inflammatory properties may help reduce joint stiffness and swelling, may improve flexibility, function, and damage from all forms of arthritis.
All of the ingredients have then been carefully chosen and may work synergistically, meaning the supplement may be more effective than the sum of its parts. This is all while offering a 90-day full money back guarantee on every bottle, which makes it a risk- free purchase.
Ingredients: glucosamine sulfate, chondroitin sulfate, omega-3 fatty acids, curcumin extract (turmeric), ginger and blue galangal extracts, bromelain, resveratrol, boswellic acid, MSM (methylsulfonylmethane), vitamin K, and vitamin D.
Pros
Some research suggests the ingredients may relieve pain and boost joint health
The formula has been designed so the ingredients make each other more effective
May offer other health benefitsÂ
Every purchase comes with a 90-day money back guarantee
Conclusion
FlexAgain is easily the best joint supplement on the market in 2025 if you’re looking for an all-in-one. Packed full of well balanced, optimally dosed, natural ingredients, it may help keep the joints healthy and ease joint pain from every angle, leading to a higher quality of life, while being a risk-free purchase.Â
Joint Buddy - Best Value
Joint Buddy is another of the newer joint supplements on sale, and is a product that claims to be specially made to provide significant joint pain relief, without costing a fortune. It tries to achieve this by combining widely used ingredients like glucosamine and chondroitin with less common natural remedies.
It claims to make the bones and joints stronger, improve connective tissue and cartilage health, and growth and repair. It may help combat inflammation and stiffness, function, flexibility, and lubrication.
It may even offer some benefits not linked to your joints. It claims to help with cholesterol, blood sugar, blood pressure, and energy levels, among other benefits.
Ingredients: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, vitamin E, selenium, zinc, copper, boron, manganese, chromium, glucosamine sulfate, chondroitin sulfate, green lipped sea muscle, MSM, l-histidine, alfalfa powder, yuca, devil's claw, and CMO (cetyl myristoleate).
Pros
Contains potent doses of a wide range of natural ingredients
May offer benefits beyond just supporting the joints
One of the more reasonably priced joint supplements on the market
Conclusion
Joint Buddy is comfortably one of the very best joint supplements on the market today. It is a fantastic option for people who want to achieve results but do not want to spend quite as much money.
Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D - Best Budget Option
Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D is a gluten, lactose, milk, soy, preservative, sugar and wheat free supplement that combines the three ingredients in its name with two other joint remedies, MSM and boswellia serrata extract.
Its anti-inflammatory properties claim to help keep the joints, bones, and connective tissues healthy, reduce joint pain, and improve joint flexibility. It may help prevent a vitamin D deficiency, which can lead to impaired joint health. This is all while being very reasonably priced.
Ingredients: glucosamine, chondroitin, vitamin D, MSM and boswellia serrata extract.
Pros
All of its ingredients are meant to support the joints
One of the most reasonably priced joint supplements
Gluten, lactose, milk, preservative, soy, sugar and wheat free
Conclusion
Puritan's Pride Triple Strength Glucosamine Chondroitin With Vitamin D is an effective joint supplement and a great option for people who are shopping on a very tight budget.
Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root - Best For Vegans
Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root is a vegan joint supplement that contains both glucosamine and chondroitin. This is quite rare as they usually come from sources that are not suitable for vegans, such as fish oil or shellfish.
In this instance, the glucosamine comes from a fungus called aspergillus niger, while phytodroitin is a synthetic version of chondroitin grown in a lab. Burdock root extract is another great alternative to fish oil for vegans, as it is full of omega-3 fatty acids, while the MSM comes from its regular plant sources.
Ingredients: vegan glucosamine sulfate sodium, vegan MSM, burdock root 4:1 extract, and phytodroitin.
Pros
Suitable for vegans and people with fish oil or shellfish allergies
Almost all of its ingredients are meant to relieve pain and improve joint health
Very reasonably priced
Conclusion
Vimerson Health Vegan Glucosamine Chondroitin MSM & Burdock Root is comfortably one of the best joint supplements available for vegans.
Nordic Naturals Vegan Algae Omega - Best For Joint Lubrication
Like the prior supplement, Nordic Naturals Vegan Algae Omega is a suitable option for vegans or people who are allergic to fish oil or shellfish. The difference here though, is that it only contains one active ingredient, which is omega-3 fatty acids.
An essential nutrient that may help lubricate the joints, the anti-inflammatory properties of omega-3s may reduce inflammation, joint pain, C reactive protein production, and all types of arthritis pain, as well as potentially promoting the growth and repair of connective tissues.
Ingredients: omega-3 fatty acids from marine algae oil, high oleic sunflower oil, and rosemary extract.
Pros
Rich in omega 3s, which may be a potent anti inflammatory
Suitable for use by vegans and those allergic to fish oil or shellfish
Very reasonably priced
Conclusion
If you want to use omega-3s and are vegan or have a fish oil or shellfish allergy, Nordic Naturals Vegan Algae Omega may be one of the best options you have available to try.
Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM - Best For Psoriatic Arthritis Symptoms
Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM is a fairly priced, GMO, shellfish and gluten free supplement designed to improve joint health, mobility, and flexibility. As the name suggests, it contains hyaluronic acid, glucosamine, MSM, and chondroitin.
All of these ingredients may help relieve joint pain, support cartilage, and improve joint cushioning. The presence of hyaluronic acid may offer a number of unique benefits for other parts of the body as well, specifically with regards to the eyes and the skin.
Ingredients: shellfish free glucosamine hydrochloride, chondroitin sulfate, MSM, and BioCell Collagen II, (undenatured type ii collagen, chondroitin sulfate, and hyaluronic acid).
Pros
Only uses gluten, GMO and shellfish free ingredients
Very reasonably priced and easy to get hold of
Conclusion
The range of benefits Solgar Glucosamine, Hyaluronic Acid, Chondroitin, MSM offers means it is a better option than most other supplements for people who are seeking arthritis pain relief.
U.S. Doctors' Clinical Arthro-7 Healthy Joint Support - Best For Rheumatoid Arthritis Pain
U.S. Doctors' Clinical Arthro-7 Healthy Joint Support is a GMO and gluten free supplement specifically designed for people dealing with rheumatoid arthritis. It is made exclusively from ingredients that may both treat and prevent rheumatoid arthritis symptoms and pain.
It may reduce inflammation, swelling and pain, aid the growth of cartilage and connective tissue, boost joint lubrication and mobility, keep your eyes and body healthy, and may help with weight management.
Ingredients: Vitamin C, undenatured type ii collagen, CMO, lipase 30, MSM, turmeric, and bromelain
Pros
Very reasonably priced and easy to get hold of
It may improve joint health and treat rheumatoid arthritis
Has received positive reviews from people suffering from rheumatoid arthritis
Conclusion
If you are looking for supplements that may provide rheumatoid arthritis pain relief, U.S. Doctors' Clinical Arthro-7 Healthy Joint Support is one of the better options you have available to try.
Physio Flex Pro - Best For Osteoarthritis Pain
Physio Flex Pro is one of the top chondroitin and glucosamine supplements on the market to help treat osteoarthritis symptoms and pain. This is because it claims to both combat joint pain directly and may help the body absorb calcium.
It may combat all osteoarthritis symptoms, but it is especially useful for treating knee osteoarthritis. It may help improve joint function, flexibility, and lubrication, and ay help repair damaged cartilage, boost the production of cartilage and synovial fluid, and help keep the joints generally healthy.
Ingredients: Selenium citrate, glucosamine HCL, bromelain (from pineapples), ginger root extract with 5% gingerols, turmeric extract with 95% curcuminoids, chondroitin sulfate, MSM, and black pepper fruit extract.
Pros
Specifically designed for osteoarthritis, especially knee osteoarthritis
May reduce joint discomfort and stiffness, improve joint health, and repair damaged joints
Conclusion
If you are suffering from osteoarthritis, Physio Flex Pro is still one of the better options you have available to try.
Nuzena Joint Support + - Best For Knee Pain
Nuzena Joint Support + is a GMO, sugar, hormone and gluten free joint supplement made to help people improve the health of their joints and prevent or treat joint pain, without costing a fortune. It contains quercetin, which may make it useful for people with mild knee pain.
However, the presence of quercetin also means it is not suitable for use by people who are taking blood thinners. Â
Ingredients: MSM, boswellia extract, bromelain, turmeric, chondroitin and glucosamine sulfates, quercetin, and methionine.
Pros
Contains ingredients that may reduce joint pain and inflammation
One of the cheapest, easiest to obtain joint supplements
Ideal for people who suffer from painful knees
Conclusion
Nuzena Joint Support + is one of the milder joint supplements and cannot be used by everyone. However, if you are looking for reasonably priced products to relieve mild pain in your knees, it may still be a good option to try.
Relief Factor - Most Popular
Relief Factor is a supplement made from only natural anti-inflammatory ingredients that may improve joint health and pain levels at the same time, while also benefiting your health in general. This has led to it becoming one of the more popular joint supplements.Â
Ingredients: omega-3 fatty acids, turmeric phospholipid, epimedium aerial, Japanese fleeceflower, cellulose capsule, cellulose powder, stearic acid from a vegetable source, silica, gelatin, glycerine, vitamin E (as natural d-alpha tocopherol) from soy, and an enteric coating.
Pros
Contains some ingredients that may provide joint support
Very popular
Conclusion
If you prefer to use popular products that are supported by word of mouth, Relief Factor may be a good option for you to try.
Final Thoughts On The Best Supplements To Relieve Arthritis Pain & Joint Damage In 2025
Some studies suggest that certain supplements may help prevent or treat joint pain along with medications you are prescribed from a healthcare provider. Elm & Rye supplements may be the best option for single ingredients, and for combined supplements, FlexAgain is easily the best supplement of this kind on the market today.
