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Due to the fast pace of modern life, more and more people are developing elevated stress levels and anxiety symptoms. For most people, these stress and anxiety disorders may be mild, and they may be rectified using simple stress reduction techniques, such as meditation, relaxation, or a healthy diet.
For chronic stress or anxiety symptoms though, alternative treatments may be helpful. This may mean anything from seeking professional medical advice and prescription medications to using natural remedies based on traditional medicine.
Natural supplements may be one way to help anxiety and stress. The problem is, with so many vitamins and supplements for stress and anxiety management out there, it is hard to know which to use. This list of the 10 best vitamins and supplements of this kind in 2025 can help everyone find the right choice to help ease stress and anxiety.
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Reviewing The 10 Best Natural Supplements For Anxiety Disorders In 2025
Here’s a list that features a perfect option for each and every person, based on things like ingredients, potential effects, form, and price.
Nootrum Mushrooms
Kittie
MushGooms Gummies
EstroCare
RestAgain
Hunter Focus
Brain Omega
Desert Harvest Vitamin D-3 With Super Strength Aloe Vera
Feedamind
- Best For Generalized Anxiety Disorder
Elm & Rye Ashwagandha contains pretty straightforward ingredients; it’s just good old ashwagandha. And Elm & Rye is the best maker of single ingredient supplements on the market right now, with some of the strictest testing, making this the best option. Ashwagandha is one of the most popular natural remedies in Ayurvedic medicine, as it purports to benefit health in many ways, while black pepper may make it easier to absorb and more effective.
Some studies suggest that it helps reduce stress and anxiety, helps combat insomnia, and may have other benefits. This is all while being extremely reasonably priced.
Pros
Extremely reasonably priced
Ashwagandha may help anxiety
Conclusion
Elm & Rye is a great option for people looking to take ashwagandha, a supplement that may help combat anxiety.
Nootrum Mushrooms - Best Blended Mental Health Supplement
Nootrum Mushrooms is an herbal supplement that contains medicinal mushrooms. Using potent 20:1 extracts of the 10 best medicinal mushrooms, it may help reduce anxiety symptoms and stress levels.
By potentially also improving brain function and health, it may help reduce anxiety symptoms and relieve stress, while also potentially preventing other mental health conditions that could exacerbate the issue, such as brain fog, cognitive decline, mood swings, and mental fatigue.
This is all while being reasonably priced and even offering a number of physical health benefits, such as improved gut, heart, liver, muscle, prostate, testicle and immune and central nervous system health and functions, and lower blood pressure, blood sugar, cholesterol and inflammation levels.
Ingredients: cordyceps mushrooms, reishi mushrooms, shiitake mushrooms, lion's mane mushrooms, and a blend of maitake mushrooms, turkey tail mushrooms, chaga mushrooms, royal sun agaricus mushrooms, white button mushrooms, and black fungus extract.
Pros
Only contains potent doses of high quality medicinal mushrooms
May boost your overall physical and mental health and functions
Very reasonably priced
Conclusion
Nootrum Mushrooms is arguably the best supplement for potentially reducing anxiety and stress in 2025, as well as for brain health overall. Packed with optimal doses of medicinal mushrooms, it may naturally enhance all aspects of your mental health.
Kittie - Best For Women
Kittie is a reasonably priced, allergen and artificial additive free supplement specifically designed to combat the symptoms many women experience when they are on their period. This may make it a great option to help support mood regulation and relieve or prevent anxiety throughout your menstrual cycle.
It also claims to help all of the other symptoms that hormonal imbalances and premenstrual syndrome (PMS) may cause. This includes cramps, breast or joint pain, acne, sleep issues, weight gain, fatigue, and cravings.
It also claims to improve your bone, eye, brain, gut, immune system, and help reduce inflammation, without costing a fortune.
Ingredients: lactobacillus paragasseri, evening primrose oil powder, vitamin E, vitamin b6, ginkgo biloba, vitex agnus castus (chaste tree) berry extract, 10:1 ginger extract, iron, vitamin D, 5-HTP (5-hydroxytryptophan), ginseng extract, and magnesium glycinate.
Pros
Only contains proven, high quality, natural, optimally dosed ingredients
May help you stick to a balanced diet
May help support the female body from all angles
Very reasonably priced
Conclusion
Kittie is easily the best PMS supplement on the market today and is a fabulous option that may help women either prevent or treat the stress or anxiety that the hormonal imbalances they experience during their menstrual cycle may cause.
- Best Gummies
Elm & Rye’s Gummies is another mushroom supplement that has a similar selection of medicinal mushrooms to Nootrum Mushrooms. However, as this time they've been made into great tasting raspberry gummies, it is an ideal choice for people who can't or don't like swallowing pills or capsules.
A totally natural, vegan friendly, GMO free supplement with a very reasonable price tag, they may be used by pretty much anyone seeking stress or anxiety relief. They may also boost your overall brain health and functions.
Ingredients: cordyceps mushrooms, reishi mushrooms, shiitake mushrooms, lion's mane mushrooms, maitake mushrooms, turkey tail mushrooms, chaga mushrooms, royal sun agaricus mushrooms, white button mushrooms, and black fungus extract.
Pros
Contains potent extracts of 10 medicinal mushrooms
Gummies are ideal for people with issues swallowing pills or capsules
Natural, vegan friendly, GMO free and very reasonably priced
Conclusion
One of the best mushroom supplements around and comes in gummy form, it is an ideal way for people who don't like swallowing pills or capsules and are looking for a supplement to help with stress and anxiety relief.
EstroCare - Best For Older Women
EstroCare is a supplement designed to help women deal with the chronic stress and anxiety disorders that are caused by hormonal imbalances. This one is specifically designed for older women, as it is created to combat menopause symptoms.
Packed with things like vitamin D, B vitamins and medicinal herbs, it may combat all anxiety and stress related symptoms, including things like mood swings and depression. This is all while also potentially helping with the physical symptoms of the condition, such as hot flashes, night sweats, and sleep issues.
It may be a fantastic option for women who know that their stress or anxiety disorder is caused by the menopause.
Ingredients: DHEA, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, iron, zinc, black cohosh, red clover, ginseng extract, bifidobacterium animalis, lactobacillus gasseri, chromium, soy isoflavones, 5-htp (5-hydroxytryptophan), calcium citrate, magnesium, maca root extract, and Siberian rhubarb extract.
Pros
My help with mood regulation and stress and anxiety relief
Only contains optimal doses of ingredients
May help with other menopause symptoms
Conclusion
EstroCare is designed for older women who are looking to combat the anxiety and other mental health issues that the menopause may cause.
RestAgain - Best For Sleep Disturbances
RestAgain is a natural sleep aid made from optimal doses of high quality natural ingredients. A great option for combatting sleep issues potentially related to anxiety, ingredients like ashwagandha and magnesium may help you sleep while getting to the root of the issue.
It may help you fall asleep faster, sleep deeper, and wake up feeling refreshed, and may help promote relaxation and calmness. This makes it a great option for people who are at an increased risk of sleep disturbances.
If you are looking to combat the sleep issues that anxiety may cause, there simply is not a better option for you to try.
Ingredients: melatonin, 5-HTP (5-hydroxytryptophan), GABA, ashwagandha root, l-theanine, magnesium, valerian root, calcium, vitamin B6, vitamin B12, and vitamin D.
Pros
A potentially powerful natural sleep aid
Only contains optimal doses of natural ingredients
Has a very reasonable price tag, serving size, and money back guarantee
Conclusion
RestAgain was not specifically designed to tackle anxiety. However, it is good at dealing with the sleep issues that people who are anxious often face.
Hunter Focus - Best For Ginkgo Biloba
Hunter Focus is a potent brain supplement made using optimal doses of a wide range of high quality, natural ingredients like B vitamins. However, perhaps its biggest selling point is the inclusion of ginkgo biloba, a natural herbal extract that may boost your mental well being.
As a result, the supplement may improve your memory, focus, mental clarity, and sleep quality, and manage stress, anxiety, mental fatigue, mood swings, and brain fog.
It may even offer benefits not linked to the brain too, like improved heart, nerve and immune functions, and general health and fitness.
Ingredients: vitamin B6, vitamin B12, vitamin B9, vitamin C, vitamin D, vitamin K, acetyl l-carnitine, l-tyrosine, lion's mane mushroom extract, l-theanine, bacopa monnieri, ashwagandha root extract, panax ginseng, ginkgo biloba, Spanish sage, citicoline, caffeine anhydrous, maritime pine bark extract, phosphatidylserine, and rhodiola rosea extract.
Pros
Full of natural ingredients that may help support brain health and functions
Every ingredient is high quality and optimally dosed
Very well reviewed by most previous customers
Conclusion
Hunter Focus is unquestionably one of the better herbal supplements designed to combat anxiety disorders and improve your mental health, and it is an especially good choice for people who are looking to use ginkgo biloba to do so.
Brain Omega - Best For Omega 3 Fatty Acids
Brain Omega is a unique nootropic supplement, as its formula relies almost exclusively on omega-3 fatty acids. Best known for their anti-inflammatory properties and ability to support the bones and joints, some studies suggest they may also help support the brain as well.
Brain Omega claims to slow the release of stress hormones, relieve anxiety, and provide a range of mental health benefits that includes improved mental clarity and memory. This is all while being dairy, gluten and soy free, so it is suitable for use by most people.
Ingredients: high DHA Omega-3s (fish oil concentrate containing DHA and EPA), Lutemax 2020 (lutein and zeaxanthin), gelatin, fatty fish oil (anchovy, sardine and mackerel), vitamin E, and sunflower oil.
Pros
Contains a potent dose of omega-3 fatty acids
May slow the release of stress hormones
Conclusion
With its potent anti-inflammatory properties, Brain Omega may slow the body's stress response to reduce anxiety.
Desert Harvest Vitamin D-3 With Super Strength Aloe Vera - Best For Vitamin D
Vitamin D, also known as the sunshine vitamin, may also help control the body's stress response. As far as supplements to make the most of these benefits go, none are as good as Desert Harvest Vitamin D-3 With Super Strength Aloe Vera.
Not only may it help you achieve optimal vitamin D levels, but it also contains aloe vera, which may help lower blood sugar levels. It pairs the two together to help support your physical and mental well being in a variety of different ways.
Ingredients: vitamin D3, organic aloe vera leaf and inner gel, tapioca starch capsules and silicon dioxide.
Pros
Contains potent doses of two natural ingredients
Very reasonably priced
Conclusion
Desert Harvest Vitamin D-3 With Super Strength Aloe Vera is a great option for people who hope to use the sunshine vitamin to improve their stress response and mental well being.
Feedamind - Best For B Vitamins
Feedamind is a potent brain booster packed with one of the best ranges of B vitamins you will find in a nootropic supplement — and these may be among the best vitamins for people who are dealing with stress or an anxiety disorder. It pairs them with other natural ingredients that may have similar effects.
A particularly good option for people who suffer from ADHD (attention deficit hyperactivity disorder), it may help the body adapt to the increased stress hormone production the condition may cause. It may then offer benefits like enhanced memory and concentration and a lower risk of brain fog or mental decline.
Ingredients: vitamin B1, vitamin B6, vitamin B7, vitamin B12, l-tyrosine, l-theanine, bacopa monnieri extract, marigold flower extract, resveratrol, pterostilbene, alpha-gpc (l-alpha-glycerylphosphorylcholine), oat straw extract, cat's claw extract, chocamine, and dyamine.
Pros
A good option for people with ADHD
Contains a greater range of B vitamins than most nootropic supplements
Conclusion
Feedamind is rich in B vitamins and other supplements for the brain.
Final Thoughts On The Best Dietary Supplements To Reduce Anxiety Symptoms In 2025
Vitamins and supplements may help the body adapt to anxiety and stress and Elm & Rye or Nootrum Mushrooms may be the best supplements of this kind.
